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If you're new here, you may want to subscribe to my RSS feed. Thanks for visiting!  I came across this short but very interesting video of Dr. J. Joseph Prendergast. For those who don’t know Dr. Joe (as he prefers to call himself), he is the product formulator of ProArgi-9 Plus. Dr. Joe is Board Certified in Internal Medicine as well as Endocrinology and Metabolism. He is an expert in integrative L-arginine therapy and has been using this type of therapy in his practice since 1991.
Due to family heredity Dr. Joe was diagnosed at the age of 37 with severe atherosclerosis or hardening of the arteries. It was estimated that he had the cardiovascular system of an 80 year old individual. This led him on a quest to find a solution to his health problem. Using cutting edge research from Dr. John Cooke and Nobel Prize winning science from Dr. Louis Ignarro and others, Dr. Joe began to work on L-arginine / L-citrulline formulations; formulations that would positively impact the health of the endothelial cells and their ability to repair themselves and produce Nitric Oxide.
The results not only benefited Dr. Joe, by reversing his atherosclerosis, but also his patient population of diabetics who had been suffering from cardiovascular issues. Prior to his discoveries on how to effectively use L-arginine and L-citrulline, Dr. Joe use to refer many of his patients for by-pass surgery. Since becoming an expert in integrative L-arginine therapy this has changed dramatically. In fact, Dr. Joe makes the following statement in this video:
“. . . 80% of the people have diabetes and in 17 years we have had no problems with strokes, no problems with heart attacks, I’ve not even had any admissions in 17 years. So this is a striking example in how we can use this product for real power for health. . . “
I would ask you to think about that. Over the last 17 years Dr. Joe has had no admissions to the hospital for cardiovascular disease. This is remarkable when you consider that most of his patients are diabetics. It was so remarkable that the American Diabetes Association awarded Dr. Joe the Father of the Year award for 2008.
Please click on “ProArgi-9 Plus” below to view this video!
Please Note: This link takes a couple of seconds to load. Once it loads you have to click on the “play button” for it to start. It then takes a couple of seconds to play. Please be patient for what Dr. Joe has to say is well worth waiting for!
Thank you for taking the time to watch this short but powerful video. I’d like to leave you with one important question:
How would your life change if you where one of Dr. Joe’s patients, especially if you’re a diabetic?
I’ll let you answer that question privately. I want to thank Dr. Joe for taking his personal health challenge, combining it with cutting edge vascular research, Nobel Prize winning science, and proven clinical results to create ProArgi-9 Plus. A product that has helped both him and thousands of others improve their health.
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 Sickle cell disease primarily affects people of African, African American, Mediterranean, Middle Eastern, and Asian Indian ancestry. There is also a growing segment in the Latino-American population particularly those of Caribbean, Central American, and South American ancestry that are affect by this disease. In the United States one out of every 400 births has this disease. The most common type of sickle cell disease is sickle cell anemia. In my companion article “African Americans and Sickle Cell Anemia” I covered a lot of material about the cause and symptoms of this disease.
This article will provide you with 14 helpful steps in managing this disease. Plus, new research confirms the importance of proper nitric oxide production in helping to reduce the painful symptoms of sickle cell anemia.
Brief Overview of Sickle Cell Disease!
Sickle cell disease is caused by a genetic change in the hemoglobin portion of the red blood cell. Hemoglobin is the oxygen-carrying protein inside the red blood cell. Normal red blood cells are oval and flexible. Red blood cells in sickle cell disease have a tendency to reshape themselves into rod-like structures that resemble the curved blade of a sickle; thus, the term sickle cell.
Sickle cells have a much shorter life span than normal red blood cells. This results in chronic anemia and reduced oxygen to the tissues of the body. In addition, sickle cells are less flexible than normal red blood cells. This presents a problem. They become trapped in the small blood vessels preventing blood flow to the body’s tissues and organs. This compromises the delivery of oxygen and usually results in pain and potential damage to the associated tissues and organs.
Recent Research – The Importance of Nitric Oxide!
Researchers at Duke University and Howard Hughes Medical Institute recently discovered one of the keys to the cause of pain in sickle cell disease. Their findings were reported in the January 31, 2005 Proceedings of the National Academy of Sciences. Their research showed that when normal red blood cells move through the arteries they release a signaling molecule that tells the arterial walls to expand. The signaling molecule is nitric oxide. Nitric oxide causes the smooth muscle in the wall of the blood vessel to relax. This helps to open up the blood vessel allowing the red blood cells to pass through it.
The researchers at Duke University discovered that when red blood cells distort to their sickle shape, the walls of the arteries don’t expand. This distorted shape of the sickle cells, combined with the fact that they tend to clump together, ends up blocking blood flow through these small arteries and capillaries. The Duke researchers also noted that as the blood pulses, the walls of the arteries didn’t expand like they do when normal red blood cells are present.
Their research also noted that the degree of nitric oxide deficiency directly correlated with symptom severity for those with sickle cell disease. This means that the less nitric oxide produced the greater the pain. The Duke/HHMI study found that when nitric oxide was administered to people with sickle cell anemia their symptoms were relieved. One of the conclusions from this study was that abnormal nitric oxide processing may be the real cause of sickle cell circulatory restrictions. In addition to the Duke/HHMI study, several other studies have demonstrated that when nitric oxide is administrated to people with sickle cell anemia their symptoms are greatly reduced.
1998 Nobel Prize in Medicine!
In 1998 the Nobel Prize in Medicine was award to three American researchers. Part of what came out of their research was that the primary pathway for creating nitric oxide in the body came from an essential amino acid called L-arginine. L-arginine is called an essential amino acid because your body cannot produce it. It must be brought into your body through your diet. L-arginine is found in foods like milk, cheese, yogurt, meat, and other proteins. In fact, L-arginine is considered one of the most important molecules ever discovered. Columbia University refers to L-arginine as the “MAGIC BULLET” for the cardiovascular system.
Genetic Polymorphism and the Importance of L-citrulline!
Unfortunately, there is a genetic polymorphism common to the African-American community. Many African-Americans produce too much of an enzyme called arginase. In the bloodstream, arginase destroys L-arginine so that it is no longer available for the production of nitric oxide. This compounds the problem of not have a sufficient supply of nitric oxide available to help relax the small arterial walls. This is especially important when the red blood cells change into their sickle form.
Fortunately, there is an amino acid that your body can convert to L-arginine to help bypass the arginase enzyme. It is L-citrulline. A recent paper (January 18, 2010) entitled Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease by MF McCarty discussed this very issue. Here is a brief but important quote from this paper:
“Suboptimal endothelial arginine levels, reflecting increased plasma arginase activity and elevated ADMA, contribute to the loss of NO bioactivity in sickle cell disease; supplementation with the arginine precursor citrulline may ameliorate this defect.”
This means that proper dietary supplementation using the amino acid L-citrulline can help the body bypass the destructive effects of the enzyme arginase so that proper nitric oxide production can be restored. Since nitric oxide regulates the muscle tone of blood vessels this becomes extremely important in preventing blockages. Additionally, nitric oxide prevents blood platelet cells from grouping together in a clot which also helps to prevent blockages in the blood vessels.
14 Steps to Help Those with Sickle Cell Disease!
Understanding the past and most current research will help to chart a plan of action to help those who suffer from sickle cell disease. The following 14 steps will help in this process. However, please remember that these steps are for informational purposes only and is not a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding this or any medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this article. If you think you may have a medical emergency, always call your doctor or 911 immediately.
Step 1 – Proper hydration. It’s estimated that 75% of Americans have mild, chronic dehydration. This will affect blood flow so getting the proper amount of water on a daily basis is critically important. And, it must be pure water! Pop, coffee, diet soda, alcohol, or other doctored beverages do not count. Your body must replace 2-3 quarts of water everyday. As a rule of thumb, for every 15 lbs of weight, you need 8 ounces (1 cup) of water.
Step 2 – Stay warm. Cold reduces blood flow because capillaries constrict. If you live in a cold environment, then take extra precaution to keep your extremities, especially fingers and toes, properly protected.
Step 3 – Avoid high altitudes. Geographic locations with high elevations should be avoided due to the reduce level of oxygen in the atmosphere.
Step 4 – Exercise. Intense exercise should be avoided but mild to moderate aerobic exercise can be a benefit. Exercise improves blood flow. Research has shown that blood flow across the endothelial cells will stimulate nitric oxide production. Additionally, exercise will produce collateral capillary beds that can aid in providing alternative pathways for blood flow when an arterial pathway becomes blocked. Collateral capillary beds are extremely important for those with sickle cell disease. However, before starting an exercise program, you should always consult your physician.
Step 5 – L-arginine supplementation. The body utilizes L-arginine to create nitric oxide. Nitric oxide is necessary for the proper function of the cardiovascular system especially in the control of the elasticity of the arterial walls.
Now, before you go out and start buying L-arginine supplements you need to be aware of the dark side of this amino acid. L-arginine ingested in its pure form tastes terrible. By itself, L-arginine can have some serious side effects. Because L-arginine can have negative side effects it must be properly formulated if it is to have a positive impact on helping the body create nitric oxide. It is critical that the company and the person who formulates an L-arginine product have both experience and clinical documentation to its effectiveness.
From my experience, the best L-arginine supplement comes from Synergy WorldWide. Their product, ProArgi-9 Plus, was developed by Dr. Joe Prendergast who is Board Certified in Internal Medicine as well as Endocrinology and Metabolism. Dr. Prendergast is an expert in integrative L-arginine therapy and has been using it in his practice since 1991. As a precaution, you should discuss this with both your physician and pharmacist especially if you are on any type of medication.
Step 6 – L-citrulline supplementation. This step is as important as step number 5 and maybe even more important. Usually L-arginine provides a 30 minute to 2 hour window of improved nitric oxide production. By supplementing with L-citrulline that window of improved nitric oxide production increases to 24 to 36 hours. When properly combined with L-arginine and other important heart healthy ingredients, this dramatically improves the endothelial cells ability to properly produce nitric oxide, the master signaling molecule for the cardiovascular system. This is an important component in ProArgi-9 Plus.
Step 7 – Rest. It’s important to get adequate rest since stress can have a negative effect on your overall health and wellness as well as lowering your immune system.
Step 8 – Support your immune system. There is so much that could be said in this area. Increasing your consumption of antioxidant rich fruits and vegetables would be an important first step. Daily consumption of at least 500 mg of vitamin C would help both the immune system and liver function.
Step 9 – Support your liver. Again, there is so much that could be said in this area. Adequate amounts of green leafy vegetables with proper water intake are two good first steps to help the liver. Taking 500 mg of vitamin C will help increase the rate of synthesis of glutathione which is a major component in liver detoxification.
Step 10 – Avoid people with colds and flu. Try not to place yourself in situations that allow for infections to occur. This may require you to use a mask if your work or school environment is compromised with illness issues.
Step 11 – Immunizations. Stay up-to-date with the proper immunizations. Work with your health care provider to set up a schedule so that all the proper steps are taken to stay on top of this area.
Step 12 – Folic acid supplementation. Folic acid is a necessary component for the production of red blood cells. The recommended daily amount for adults is 400 micrograms and 600 micrograms in pregnancy. If you are thinking about taking a larger amount, then you should discuss this with both your physician and pharmacist. This is an important component in ProArgi-9 Plus.
Step 13 – Support groups. Because of the emotional challenges that come with sickle cell disease it always helps to find a support group to share frustrations, challenges, hopes, and successes.
Step 14 – Family planning. Due to the genetic nature of sickle cell disease, it’s always helpful to discuss options with a family practitioner who has experience in genetic counseling.
Because of the genetic nature of sickle cell disease there is no pill to cure it. This can leave individuals and family members feeling helpless in their battle against the symptoms of this disease. That’s why it’s important to discuss these 14 steps with a qualified physician. Together you can develop a plan of action; one that will empower you to have better control over the symptoms of sickle cell disease.
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 Recent research on sickle cell anemia has shown how improving nitric oxide production can make a significant difference in symptom severity. I’ve written about this in my article “Nitric Oxide and Sickle Cell Anemia!” The purpose of this article is to provide a basic understanding of this genetic disease.
Although African Americans are affected the most by sickle cell disease, it can affect Mediterranean, Middle Eastern, and Asian Indian ancestry. There is a growing segment in the Latino-American population particularly those of Caribbean, Central American, and South American ancestry who are also affected by this disease.
In the United States one out of every 400 births has this disease. The most common type of sickle cell disease is sickle cell anemia.
Definition and Description of Sickle Cell Disease
Sickle cell disease is a group of inherited blood disorders that center on red blood cells. These red blood cells can function abnormally resulting in small blood clots, chronic anemia, painful events, and potential complications associated with tissue and organ damage. These blood disorders include sickle cell anemia, Mediterranean blood disease, and the sickle beta thalassemia syndromes.
All types of sickle cell disease are caused by a genetic change in the hemoglobin portion of the red blood cell. Hemoglobin is the oxygen-carrying protein inside the red blood cell. Normal red blood cells are oval and flexible. Red blood cells in sickle cell disease have a tendency to reshape themselves into rod-like structures that resemble the curved blade of a sickle; thus, the term sickle cell.
Sickle cells have a shorter life span than normal red blood cells. This results in chronic anemia and reduced oxygen to the tissues of the body. Sickle cells are sticky and less flexible than normal red blood cells. This presents a problem since they can be trapped in the small blood vessels preventing proper blood flow to the tissues. This compromises the delivery of oxygen and results in tissue pain. It also has the potential to damage the associated tissues and organs.
Carriers of the sickle cell gene are referred to as having sickle cell trait. Most of the time sickle cell trait does not cause health problems. In fact, sickle cell trait can be beneficial because it provides protection against malaria, a disease caused by blood-borne parasites transmitted through mosquito bites. It is estimated that one in 12 African-Americans has sickle cell trait.
The Cause of Sickle Cell Disease!
The hemoglobin molecule of a red blood cell is made up of three components:
- Heme
- Alpha or alpha-like globin
- Beta or beta-like globin.
Sickle cells contain a genetic change in the beta globin component of the hemoglobin molecule. This is caused by a change in the genetic coding on chromosome 11. One small change in a single DNA nucleotide results in a different amino acid being inserted into the beta globin protein of the hemoglobin molecule. This results in the unique properties of sickle cells. For simplicity we will call this altered gene the “sickle cell gene” and the regular gene the “normal red blood cell gene.”
For most individuals, they have two copies of the “normal red blood cell gene” to produce normal beta globin resulting in typical red blood cells. Individuals with sickle cell trait have one “normal red blood cell gene” and one “sickle cell gene” so they produce both normal red blood cells and sickle cells in roughly equal proportions. Because of this they do not usually experience significant health problems as a result of having sickle cell trait. Those with sickle cell anemia have two “sickle cell genes.”
Genetics play a significant role in both the disease, symptoms, and in family planning. If both members of a couple have sickle cell trait, then there is a 25% chance in each pregnancy for the baby to inherit two sickle cell genes. The resulting child will have sickle cell anemia. Correspondingly, there is a 50% chance the baby will have sickle cell trait and a 25% chance that the baby will have the “normal red blood cell genes”.
If both members of a couple have sickle cell anemia, then the baby will have sickle cell anemia 100% of the time. If one member of the couple has sickle cell anemia and the other has both “normal red blood cell genes”, then the resulting child will have sickle cell trait 100% of the time. Finally, if one member of the couple has sickle cell trait and the other has both “normal red blood cell genes”, then the resulting child has a 50% chance of having normal red blood cell hemoglobin or a 50% chance of having sickle cell trait.
The Need for Oxygen!
Oxygen is necessary for life and the optimal function of all cells. Red blood cells transport the oxygen from your lungs to the tissues of your body. It’s the hemoglobin molecule that binds oxygen to itself in the lungs. It then releases oxygen to the tissues for proper cell respiration. However, once the oxygen is released by the sickle cell hemoglobin it can cause the red blood cell to alter its normal oval shape into the rigid, sickle shape characteristic of sickle cells. Low oxygen can be a trigger for this change. Studies also seem to indicate that cold temperatures and dehydration can be additional factors in triggering this change.
Normal red blood cells can survive for approximately 120 days where as sickle cells typically last 10-12 days. This is an important factor because it leaves the bloodstream chronically short of red blood cells and hemoglobin which leads to anemia. This creates its own shortage of oxygen which could trigger a shape change in the oval red blood cell to the sickle shape. This rigid, sickle shape causes circulation problems especially in small blood vessels.
In addition, there are altered chemical properties that develop which increases the cells’ “stickiness”. This is why sickle cells tend to adhere to the inside surfaces of small blood vessels, as well as other blood cells, resulting in blockages. These blockages prevent oxygenated blood from reaching the tissues resulting in pain. If kept without oxygen long enough possible organ and tissue damage can occur.
Symptoms of Sickle Cell Anemia!
Common symptoms for those with sickle cell anemia include the following:
- Bloody urine
- Bone and/or abdominal pain
- Chest pain
- Delayed growth and delayed puberty
- Excessive thirst
- Fatigue, breathlessness, rapid heart rate
- Frequent urination
- Increased susceptibility to infections, fever
- Pain which can vary from moderate to intense
- Paleness, yellow eyes and/or skin, jaundice
- Poor eyesight or blindness
- Ulcers on the lower legs usually in adolescents and adults
For those with sickle cell anemia, the severity of symptoms varies widely and cannot be predicted solely on genetic inheritance. Some with sickle cell anemia develop health and life threatening problems in infancy while others only have mild symptoms throughout their lives. Others experience various degrees of health issues as they age. Certain variations of sickle cell disease tend to have less severe symptoms than other types of sickle cell disease.
Organs Affected by Sickle Cell Anemia
Various organs and body systems can be effect by sickle cell disease. As you will see from this list, sickle cell anemia has a wide range of effects on the body. The bottom line is that any tissue that needs oxygen and adequate blood flow can be at risk.
- Acute Chest Syndrome – Acute chest syndrome or ACS is a leading cause of death for those with sickle cell disease. It takes place in the lungs. Rapid diagnosis and treatment is very important. ACS can occur at any age. It is similar to pneumonia in symptoms but distinct in its damage.
- Anemia – As we learned early, sickle cells have a life span of 10-12 days resulting in a deficiency of red blood cells in the bloodstream. It is the hemoglobin of red blood cells that carry oxygen, so with this deficiency there is a reduction in oxygen to the tissues. Common symptoms of anemia include fatigue, paleness, and a shortness of breath. The heart rate will increase. This circulates more blood helping to make up for the lack of oxygen to the tissues.
- Delayed Growth – Because of the short life span of sickle cells, the demands on the bone marrow to produce more red blood cells compete with the demands of a growing body. Children with sickle cell anemia may experience delayed growth and reach puberty at a later age. However, by early adulthood, they catch up on growth and height but may still remain below average in weight.
- Infections and the Spleen – Children under the age of three with sickle cell anemia are particularly susceptible to life-threatening bacterial infections especially from Streptococcus pneumoniae. Unfortunately, 15% of these types of cases result in death. Since your spleen helps to fight bacterial infections, it is particularly vulnerable. For those with sickle cell anemia, it is not uncommon to see the loss of spleen function by late childhood.
- Jaundice and Gallstones – Jaundice is indicated by a yellow tone in the skin and eyes due to increased levels of bilirubin. Bilirubin is the final product of hemoglobin degradation when red blood cells are destroyed. Bilirubin is removed from the bloodstream by the liver. Elevated levels can increase the chance for gallstones.
- Joint Problems – The blood supply to the connective tissues, especially in the hip and shoulder joints, can be blocked by the sickle cells resulting in bone damage and poor healing. This complication can affect an individual’s physical abilities and result in substantial and chronic pain.
- Kidney Disease – Kidneys are particularly prone to damage from sickle cells. Adults with sickle cell disease often experience reduce kidney function which can progress to kidney failure.
- Painful Events – This is the hallmark symptom of sickle cell disease. The frequency and duration varies tremendously from individual to individual and over an individual’s lifetime. These painful events are also the most common cause for hospitalization. This hallmark symptom results when the small blood vessels become blocked by the sickle cells preventing oxygen from reaching the tissues. Although pain can affect any area of the body, the most frequent sites are the extremities, chest, abdomen, and bones.
- Priapism – Only males have to deal with this since it is a condition characterized by a persistent and painful erection. Blood vessels become blocked by sickle cells so that blood is trapped in the tissue of the male’s organ. It’s extremely painful and can result in damage to this tissue causing impotence.
- Retinopathy – The blood vessels that support the tissue at the back of the eye may be blocked by sickle cells resulting in this condition. Regular ophthalmology evaluations and effective treatment can help a person avoid permanent damage to their vision.
- Stroke – This is the most concerning complication of sickle cell disease. Approximately 11% of individuals with sickle cell anemia will have a recognizable stroke by the age of 20. A stroke in a person with sickle cell disease is usually caused by a blockage of a blood vessel in the brain by the sickle cells. This results in lack of oxygen to the affected area of the brain. The consequences are far ranging from undetectable effects, to apparent or subtle learning disabilities, to severe physical or cognitive impairment, to life-threatening situations.
Diagnosis and Treatment of Sickle Cell Anemia
The inheritance of sickle cell disease or sickle cell trait cannot be prevented but it can be predicted so screening is recommended. If you exhibit symptoms, then contact your physician so that accurate tests can be done. These tests can determine if you carry the “sickle cell gene” and what level of risk you are at. For newborns, more than 40 states include sickle cell screening as part of the battery of blood tests. However, don’t just assume the test is done. You must always be proactive.
Hemoglobin trait screening is always a good choice for any person of a high-risk ethnic background especially if you are planning on having children. If you and your partner are found to have sickle cell or any other hemoglobin traits, then you might want to receive genetic counseling to better understand the risk of sickle cell disease for your offspring. There are various testing options available to you to help you in your planning.
There are various treatment options to help prevent some of the symptoms and complications of sickle cell disease. These treatment options can include:
- Access to comprehensive health care
- Adequate nutrition
- Avoiding stresses and infection
- Blood transfusions
- Bone marrow transplantation
- Getting proper rest
- Good hydration
- Hydroxyurea
- Pain management
- Proper immunizations
- Supplementation with folic acid
- Support groups
- Surgery
- Use of preventative antibiotics
As with any disease condition, you want to always work with a qualified health professional to develop a course of action that best fits your individual situation.
New Research on Nitric Oxide!
There is new research that shows a direct correlation between nitric oxide deficiency and symptom severity for those with sickle cell anemia. I will discuss this in my companion article “Sickle Cell Disease – 14 Helpful Steps!” This article discusses the latest research. It also provides 14 suggestions you can use to help those with sickle cell disease.
I hope this article has given you a better understanding of sickle cell anemia. I encourage you to take the steps to educate yourself and any loved ones who may have this health issue. We can help empower them to take the necessary steps to improve their overall health and wellness.
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 Cardiovascular disease is the number one killer of people worldwide. Unfortunately, it’s even worse for the African American community. There are several reasons for this and hopefully this article will help begin the process of changing this sad reality. To address these reasons I’ve broken this article into three parts: The Bad News, Several Underlining Causes, and Steps to Decrease Your Risk!
The Bad News!
It’s important for you to understand the depth of cardiovascular disease confronting the African American community. Below is a brief summary of the ailments that directly affect African Americans:
- Diabetes. Type 2 diabetes has grown to epidemic proportions in the United States. People with diabetes have a greater risk for stroke, heart disease and circulatory issues. Most diabetes-related deaths are due to cardiovascular disease. Twice as many African Americans will develop diabetes when compared to the Caucasian community.
- Erectile Dysfunction. Erectile dysfunction affects 50% of the male population over the age 40 and is even greater in the African American community.
- Heart Disease. African American women in the age range of 25-44 have a 2.5 times greater risk of coronary heart disease and African American men have a 1.5 times greater risk than the Caucasian community.
- High Blood Pressure. The number one risk factor for stroke is high blood pressure, and 1 out of every 3 African Americans suffers from this ailment. The American Heart Association estimates that 28% of African American adults and more than 66% of African Americans over the age of 60 have high blood pressure.
- High Cholesterol Levels. High blood cholesterol is a significant risk factor for heart disease. Unfortunately 50% of African American men and 54% of women have too much cholesterol circulating in their blood stream.
- Sickle Cell Anemia. It’s estimated that one in 12 African Americans has sickle cell trait and one out of every 400 births have sickle cell anemia.
- Stroke. African Americans are twice as likely to die from a stroke as Caucasians. The rate of having their first stroke is almost doubled that of Caucasians. One half of all African American women will die from either a stroke or heart disease. For those with sickle cell anemia, 11% will have experienced a stroke by the age of 20.
That’s quite a list of ailments affecting African Americans. If you look closely at all seven health issues you will see that the common denominator is your cardiovascular system.
The key for reducing your health risk for these cardiovascular diseases is to make sure your cardiovascular system is as healthy as possible. This article will provide several steps to address this but before we do you need to understand some of the underlining causes of why cardiovascular disease is so prevalent in the African American community.
Several Underlining Causes!
Within your cardiovascular system there is one particular essential amino acid, one critical signaling molecule, one critical cellular structure and one detrimental enzyme that directly impact its overall health. They are:
- L-arginine – Key Essential Amino Acid
- Nitric Oxide – Key Signaling Molecule
- Endothelial Cells – Key Cellular Structure
- Arginase – Key Detrimental Enzyme
The first three keys of L-arginine, nitric oxide and endothelial cells are interrelated so we will examine them as a whole. The endothelial cells form the interior lining of all your blood vessels. These cells ultimately determine your cardiovascular health. One function of these endothelial cells is to take the essential amino acid L-arginine and convert it into the signaling molecule nitric oxide. Very simply, you couldn’t live without nitric oxide!
Nitric oxide is the master signaling molecule of the cardiovascular system. It regulates blood vessel tone and flexibility. Its production is completely dependent upon the health of your endothelial cells and an adequate supply of the essential amino acid L-arginine. Here are some of the benefits of nitric oxide:
- Nitric oxide regulates the muscle tone of blood vessels to have a major impact on controlling blood pressure. This directly relates to high blood pressure.
- Nitric oxide causes penile erections by dilating blood vessels. This directly relates to erectile dysfunction.
- Nitric oxide prevents blood platelet cells from grouping together in a clot. This minimizes blockages in the blood vessels to reduce the risk for heart attacks, strokes and complications from sickle cell anemia.
- Nitric oxide promotes vascular reparative mechanisms and is one of the keys to reversing atherosclerosis. This helps to reduce the damage caused by high cholesterol levels and assists in preventing the vascular complications of diabetes.
Nitric oxide is literally involved in all cells to help keep you fit and healthy. It’s important to understand that this interrelationship between the endothelial cells, L-arginine and nitric oxide production is common for all races.
What is not common is a genetic polymorphism inherent to the African American population. This genetic polymorphism causes African Americans to have higher levels of an enzyme called arginase in their blood stream. Arginase destroys L-arginine which is the main ingredient for creating nitric oxide in the body.
For the African American community, nitric oxide production is compromised on both sides of the equation!
On the front end, the enzyme arginase destroys L-arginine which interferes with the production of nitric oxide. On the back end, the health of your endothelial cells determines how much of the remaining L-arginine can be converted to nitric oxide. Unfortunately, your endothelial cells are damaged by high blood pressure, high sugar levels, high cholesterol, smoking, and oxidative stress. This damage reduces the production of nitric oxide which compounds the problem and increases the risk for cardiovascular disease.
Steps to Decrease Your Risk!
Given the above information there are several important steps to decreasing your risk for cardiovascular disease.
Step 1 – Monitor your blood pressure. High blood pressure damages your endothelial cells. If you do not know what your blood pressure is then you need to go to your doctor’s office, local pharmacy or health clinic and get your blood pressure taken. If you have high blood pressure, then you need to take steps to bring it back into a normal range. This is your first and most important step. It’s so important that the Black Barbershop Health Outreach Program was established to exclusively address the issue of high blood pressure on a national level. For more information on participating barbershops, go to http://www.blackbarbershop.org/ .
Step 2 – Monitor your blood sugar and cholesterol levels. High sugar and cholesterol levels damage your endothelial cells. Diet is extremely important for both of these areas. One simple but highly effective step to stabilize your blood sugar levels and help your body naturally reduce its cholesterol levels is to increase your fiber intake. Including dry beans or legumes into your diet is a quick and delicious way to increase your fiber intake. In fact studies have shown that consuming dry beans four times or more per week, compared with less than once a week, lowered the risk of cardiovascular disease by 22 percent.
Step 3 – Stop smoking! Smoking damages your endothelial cells. This is a nasty habit that is extremely hard to break. Part of the process is having a motivation greater than the habit.
If your very life isn’t motivation enough, then maybe for the men your sex life is!
Your endothelial cells control your nitric oxide production. Your nitric oxide levels control an erection. No nitric oxide no sex! Every puff on your cigarette is destroying your endothelial cells which lowers your nitric oxide level and reduces your chances of having good sex.
Step 4 – Increase L-arginine intake! In addition to protecting your endothelial cells, you need to get an adequate intake of the essential amino acid L-arginine which is found in foods like milk, cheese, yogurt, meat, and other protein sources. Most people take in enough L-arginine to meet basic bodily needs. However, when your diet is poor and/or your stress level is high, then this essential amino acid will be lacking. Couple this with the enzyme arginase that destroys L-arginine and the potential risk for cardiovascular disease is increased.
Step 5 – Use L-citrulline to bypass Arginase! Your body will convert the amino acid L-citrulline into L-arginine to help maintain its production of nitric oxide. This process also helps to bypass the arginase enzyme since it has no effect on L-citrulline. Having a good supply of L-citrulline provides the body with a 24 to 36 hour window in the production of nitric oxide. This is important for all population groups but it’s critically important for African Americans especially those with sickle cell anemia. Unfortunately, L-citrulline is not prevalent in most foods we eat. Thus, supplementation is usually required.
Step 6 – Consider ProArgi-9 Plus! There is a clinically proven nutritional supplement called ProArgi-9 Plus which has the ability to bring in the proper balance of L-arginine and L-citrulline. This product also combines other heart healthy ingredients to significantly improve the health of the endothelial cells and their ability to properly produce nitric oxide. The most recent validation for this product is the remarkable results obtain for 33 congestive heart failure patients in the High Desert Heart Institute study.
Conclusion
You have the power to directly improve the health of your endothelial cells to significantly reduce your risk for cardiovascular disease. And, for those with sickle cell anemia, you can help to reduce your symptoms. It all centers on helping your endothelial cells function optimally, with an above average supply of L-arginine, and a way to bypass the arginase enzyme so that nitric oxide is properly produced. Improved production of nitric oxide is critical to helping African Americans decrease their risk for cardiovascular disease!
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 On Saturday, January 23, 2010 Dr. Siva Arunasalam, the Founder and Director of the High Desert Heart Institute gave his first public presentation of the groundbreaking results from the High Desert Heart Institute Study. This study evaluated the effects of the nutritional supplement ProArgi-9 Plus on the health of 33 congestive heart failure patients. The results of the study were “remarkable” in how a proper L-arginine and L-citrulline combination, with other heart healthy ingredients, can make positive changes in the cardiovascular system.
During the weekend event, John Hewlett of the ComoCardio Institute conducted a 15 minute video interview with Dr. Siva. While this video is posted on the ComoCardio website, I wanted to share it with my audience.
John Hewlett conducts a wonderful interview that shows a gifted health practitioner who is dedicated to finding methods that can enhance the health of his patience so that stent surgeries can be avoided.
Please click on “ProArgi-9 Plus” below to view this interview!
Video Index – I’ve also indexed the video to help you navigate to the sections that would best address your interests.
0:01 to 2:00 Introduction and Dr. Siva’s educational background
2:01 to 3:37 Next stages in cardiac intervention with L-arginine
3:38 to 5:05 Why cardiologists don’t use L-arginine intervention
5:06 to 6:02 Dr. Siva’s specialty in angioplasty and stents
6:03 to 7:25 ProArgi-9 Plus study results
7:26 to 8:56 Discussion about Vitamin K concerns
8:57 to 9:45 Discussion about stents and bypass surgery conflicts
9:46 to 10:41 Discussion about Synergy WorldWide’s involvement
10:42 to 11:43 What can these results do to help people
11:44 to 12:24 Benefits to pulmonary hypertension
12:25 to 13:35 Improvements to renal and organ function
13:36 to 14:15 Observations about neuropathy improvements
14:16 to 14:51 Closing comments
Again, I want to thank John Hewlett of the ComoCardio Institute and Dr. Siva of the High Desert Heart Institute for this interview. The information is both helpful and enlightening.
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 I have chosen to use a question mark and an exclamation mark in the article’s title, dealing with erectile dysfunction, for a reason. For some men who have recently experienced problems in the bedroom, they’re not sure if they have erectile dysfunction or not. For them it’s a question mark that needs more time to determine its final outcome.
For other men they know that their erectile dysfunction is real and they are alarmed. They’re seeking answers to their problem and searching the internet for help. For them the exclamation is a sign of worry and concern.
Finally, there are men who have never had this problem or have found solutions that have corrected their problem and are no longer dealing with erectile dysfunction. For them the exclamation is a sign of relief.
If you’re dealing with erectile dysfunction or think that you might have a potential problem in this area, then one of the most important tools to help you is good, concise knowledge. Knowledge that can help you:
- Understand that it’s a common problem for men over the age of 40.
- Find the real underlying cause.
- Develop a treatment program that can truly work for you.
This post is designed to help provide you with knowledge and a potential solution so that the question mark can become an exclamation mark based upon positive results.
The Facts about Dealing with Erectile Dysfunction!
Many men feel embarrassment so they typically try to hide the problem. They try to hide it from their partner. They try to hide it from their doctor. So the first thing you need to know is that dealing with erectile dysfunction is a common problem for men especially after the age of 40. Plus, the potential for this problem continues to increase as you get older.
Maybe not what you wanted to hear but it is truth.
The other part of the truth equation is that it doesn’t have to be this way. The health of your penis is tied to the health of your body. Many may see this as a simplistic answer but it is true for most men. It’s estimated that 70 percent of all erectile dysfunction is caused by a medical condition. Usually that medical condition centers on the health of your cardiovascular system. More specifically it centers on the endothelial cells that line all of your cardiovascular system and their ability to properly produce nitric oxide.
Dr. Arthur Burnett, a Johns Hopkins urologist and leading nitric oxide researcher will clearly tell you that nitric oxide is the chemical messenger that produces erections and that without it there could be no natural erections. This is also echoed by the 1998 Nobel Laureate in Medicine Dr. Louis Ignarro who, with 2 other American researchers, discovered how the endothelial cells produce nitric oxide to dilate blood vessels. In Dr. Ignarro’s book NO More Heart Disease he makes the following two statements:
“By 1990, our experiments indicated that NO is also the chemical messenger responsible for penile erections. Nerves in the erectile tissues release NO, dilating the blood vessels and initiating erections.” – page 11
“For many years, men with erectile dysfunction were told that they suffered from a psychological dysfunction. Most physicians claimed ‘It’s in your head,’ since they felt impotence stemmed from performance anxiety or sexual disinterest. . . . My own research has shown that the erectile tissues of men with severe erectile dysfunction produce much less nitric oxide than men without this problem. Unless there is a way to increase their NO levels, erections simply are not going to be possible.” – pages 191 & 192
If you’re dealing with erectile dysfunction then you need to understand how to determine the root cause of your problem because erectile dysfunction is a symptom of an underlining health issue. Products like Viagra, Cialis and Levitra may help you with the symptom but they usually do not help you with the underlining cause of erectile dysfunction.
In my previous post on this issue I directed you to the article “Fixing Erectile Dysfunction!” This article helps you understand how male physiology, chemistry and the nervous system all work together to create an erection. And, it briefly discussed how to enhance the endothelial cells’ ability to produce nitric oxide.
Today, I would like to direct your attention to the article “Curing Erectile Dysfunction Naturally with L-arginine and Nitric Oxide!” This article will go into greater detail about one of the best methods for curing erectile dysfunction. That method is learning how to properly use L-arginine and L-citrulline to improve the production of nitric oxide and help to repair of your endothelial cells.
Men, I hope you find these articles helpful in dealing with erectile dysfunction. They are written with the goal of removing the worry and concern about this issue so that you can find a real solution to your underlining problem. No more questions marks, just an exclamation mark based upon positive results.
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 What does a cell phone and lap top have to do with fixing erectile dysfunction? When they don’t work properly they cause emotional responses like:
Frustration, Anger, and Embarrassment!
In our high tech society we have become conditioned to expect our cell phone and lap top to work all the time and in all situations. When they don’t we become frustrated. We start looking for the instruction manual that we never bothered to read in the first place and when we can’t find it we become angry. Even when we do find it, the instructions are confusing and can accelerate our anger. When we finally take it into a Geek Squad we’re embarrassed to admit we didn’t have the technical knowhow to fix the problem.
For men with erectile dysfunction they can experience some of the same negative emotions. Like their cells phones and lap tops they expect their male anatomy to work all the time especially when the “time is right” as highlighted in the Cialis commercials.
When it doesn’t, confidence can be lost causing anxiety. With repeated failures this anxiety turns into frustration. And, when erectile dysfunction becomes chronic this frustration can become anger.
Often men who are having erectile problems feel embarrassment. He sees himself as the only one who has this problem. He worries that his partner will see him as a failure. He’s even embarrassed to bring it to the attention of his physician and may worry that there might be a more serious underlining problem.
So, how do you prevent these feelings from occurring?
Having the knowledge on how to fix the problem is the key!
Fortunately, the male organ is a whole lot easier to understand and fix then your cell phone and lap top. Having a proper understanding of erectile dysfunction is the first step in fixing erectile dysfunction. It’s more important than taking Viagra or any number of erectile dysfunctional drugs because it will help you determine the best long term solution to this symptom.
Notice I said “symptom” and not disease.
For the overwhelming majority of men who experience ED or Erectile Dysfunction it is a symptom of an underlining medical condition. Usually the medical condition centers on the cardiovascular system, the health of your endothelial cells, and their ability to properly produce nitric oxide.
To help the estimated 30 million American men who have some level of erectile dysfunction, I offer you two potential solutions to fixing erectile dysfunction. The first is an article posted on http://www.aging-no-more.com/ entitled simply “Fixing Erectile Dysfunction!” This article will help you understand how male physiology, chemistry and the nervous system all work together to create an erection. Click here to read the complete article.
Once you have a good understanding of erectile dysfunction, the second solution makes good sense because it offers a long-term natural solution for fixing the problem. Most researchers in this area believe that nitric oxide “can correct up to 90% of all penile dysfunction.”
The underlining problem is the insufficient production of nitric oxide to help start and maintain proper vasodilatation for an erection. The creation of nitric oxide occurs in the endothelial cells that line the blood vessels. The main nutrient for the creation of nitric oxide is an essential amino acid call L-arginine. By combining this with an adequate intake of L-citrulline many males have found that they don’t need to spend money on Viagra-like products to help them.
The second solution is a product called ProArgi-9 Plus. This product has been clinically shown to improve your cardiovascular system. It uses Nobel Prize winning science and cutting edge vascular research to properly bring L-arginine and L-citrulline into your body to heal the endothelial cells. This naturally produces adequate supplies of nitric oxide, and does it without side effects. All of which are important for fixing erectile dysfunction!
Together we can work to save a million lives!
Dan Hammer
Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
Confusion About the Risks of Hormone Replacement Therapy!
 Once again confusion has entered the world of hormone replacement therapy. I bring this up in a heart disease blog because the type of treatment for menopausal symptoms can have an effect on cardiovascular health.
The latest confusion comes out of an article from ThirdAge which I will link to below. The article focuses on Dr. Shelley Salpeter and her colleagues at Santa Clara Medical Center in California. They examined 19 studies involving 16,283 women with a mean age of 55 years. Dr. Salpeter and her colleagues found that hormone replacement therapy was associated with a 27 percent reduction in relative mortality risk and an absolute risk reduction of around 1 percent.
Their collective research is published in the American Journal of Medicine. They felt it was important to address the concerns raised by the Women’s Health Initiative (WHI) study that showed postmenopausal women over 63 years of age had an increased risk for heart disease, cancer, stroke and blood clotting due to hormone replacement therapy. Dr. Salpeter felt that the WHI results were poorly interpreted especially as they applied to younger women. Quoting from the ThirdAge article:
“Available evidence indicates that hormone therapy in younger postmenopausal women increases the risk of breast cancer and pulmonary embolism, and reduces risk of cardiovascular events, colon cancer, and hip fracture. The total mortality benefit for younger women seen in the randomized trials and observational studies indicates that the reduction in deaths from coronary heart disease, fracture and colon cancer outweighed the increase in deaths from breast cancer, stroke, and pulmonary embolism.”
So What Does This Mean?
It means risk / reward. It means risk using hormone replacement therapy to help with menopausal symptoms and be rewarded with the potential for less coronary heart disease, fractures and colon cancer while increasing your risk for breast cancer, stroke, and pulmonary embolism. Since the absolute risk for death has only a 1 percentage difference let’s not be overly concerned since the short term health benefits outweigh the negatives; especially since 12xs more women die from heart disease then from breast cancer.
My question is: Why not a reward / reward option! Instead of making conventional hormone replacement therapy the first option why not the last option! Why not work with a qualified health professional to look for natural and effective alternatives to peri menopausal and menopausal symptoms? Why not apply that some consultive approach with your health professional for cardiovascular solutions?
To help education you on both sides of the menopausal equation I’ve a couple of links below:
http://www.thirdage.com/menopause/hrt-reduces-mortality-risk-in-50s – This links you to the actual article from ThirdAge in case I’ve misinterpreted the information.
http://www.amjmed.com/article/PIIS0002934309006664/fulltext – This links you to Dr. Salpeter’s actual research article posted on The American Journal of Medicine’s website.
Natural Remedies for Hot Flashes! – One of the symptoms of peri menopause and menopause is hot flashes and learning how to effectively use natural remedies can be a Godsend for women.
What Causes Night Sweats! – This links to another one of my articles. For many, night sweats are even worse than hot flashes so learning what causes them and how to stop them can do wonders for your overall health.
The two articles will also provide additional links to help educate you on potential solutions to menopausal symptoms.
Together we can work to save a million lives!
Dan Hammer
The information contained in this blog is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this blogging website has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
Can the Cure for Hot Flashes be a Cardiovascular Health Issue?
 You may be wondering why a blog on heart disease would contain a post on the cure for hot flashes. The answer lies in the Women’s Health Initiative (WHI) study. This study was launched in 1991 and included 161,808 generally healthy postmenopausal women. It was designed to be a major 15-year research program to address the most common causes of death, disability and poor quality of life in this category of women.
The clinical trials were designed to test the effects of hormone therapy, diet, and calcium and vitamin D supplements on heart disease, bone health, and breast and colorectal cancer.
The study was stopped in 2002 because the results of the study strongly suggested that conventional hormone replacement therapy for menopausal symptoms increased the risk for heart disease, cancer, stroke and blood clotting in women. Three direct health issues that involve the cardiovascular system.
This caused a surge in women looking for natural remedies for peri menopause and menopausal symptoms. Remedies that would protect themselves but also help relive symptoms like hot flashes! This surge created a tremendous amount of confusion which still persists today.
To help address this issue I’ve two articles you can link to.
Natural Remedies for Hot Flashes! – This article will address one of the most annoying of all the menopausal symptoms which is hot flashes. Learning how to effectively use natural remedies for hot flashes can be a Godsend for women who are experiencing this embarrassing and debilitating problem.
Get Rid of Your Hot Flashes and Night Sweats Once and for All! – This short video and information sheet contains my wife Sherry’s story. How we addressed one health issue of high blood pressure and in the process also completely eliminate her hot flashes and night sweats. If this video and information speaks to you, then I would invite you to join our group.
It’s estimated that 80% of women today experience some type of menopausal symptom resulting from hormonal imbalance. Depending upon your method of treatment, this could also have a potential affect on your cardiovascular system. Hopefully, these two articles will help educate you so that when you work with a qualified health professional you can design a program that improves your heart health while providing you with a cure for hot flashes.
Together we can work to save a million lives!
Dan Hammer
The information contained in this blog is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this blogging website has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
 Many in the health care profession have forgotten about the positive relationship between niacin and cholesterol. Instead they have promoted statin drugs to control cholesterol levels. That’s unfortunate because niacin can be just as effective.
What is Niacin?
Niacin is a member of the vitamin B family. Specifically it is vitamin B3 or nicotinic acid. Because it’s a water soluble vitamin it needs to be replenished on a daily basis. The recommended daily allowance (RDA) of niacin is 2-12 mg/day for children, 14 mg/day for women and 16 mg/day for men. This RDA is the minimum required to prevent niacin deficiency which can be characterized by the following conditions:
- Slow metabolism
- Decreased tolerance to the cold
- Irritability
- Poor concentration
- Anxiety
- Fatigue
- Restlessness
- Depression
- Dementia
Niacin can be obtained through your dietary intake of the following foods: liver, heart, kidney, chicken, beef, tuna, salmon, milk, eggs, avocados, dates, tomatoes, leaf vegetables, broccoli, carrots, sweet potatoes, asparagus, nuts, whole grain products, legumes, mushrooms, and brewer’s yeast.
Cooking preparation is important since niacin is readily lost when food is cooked in water. Coupled with poor eating habits and foods depleted of their essential nutrients, many people insure their niacin RDA through vitamin supplements. If you choose a vitamin supplement then it is recommended that niacin is best taken with the other B vitamins and vitamin C.
Niacin is used by your body to help turn carbohydrates into energy. Niacin also aids your nervous system, digestive system, skin, hair and eyes. Niacin is also needed to help metabolize fats, which brings us to its ability to reduce cholesterol levels.
Niacin and Cholesterol Levels
To positively affect cholesterol levels, your niacin intake must be substantially greater than the RDA. As reported in the November 1998 American Journal of Cardiology, therapeutic levels of niacin have been clearly shown to:
- Lower LDL (BAD) and total cholesterol levels.
- Raise HDL (GOOD) cholesterol levels.
- Lower triglyceride (fat) levels.
Not only does niacin lower the “Bad” LDL cholesterol but it also substantially increases the “Good” HDL cholesterol. Many feel that increasing HDL cholesterol is more important than lowering LDL cholesterol. This is because the high-density lipoproteins (HDL) will sweep up the low-density lipoproteins (LDL) in your blood stream to keep them from damaging your endothelial cells.
Niacin can raise the HDL “Good” cholesterol by 15 to 35 percent. The Mayo Clinic estimates that for every 1 milligram per deciliter increase in HDL cholesterol you reduce your risk for heart attack by 3 percent. This means that the proper therapeutic use of niacin can lower the risks for atherosclerosis and other cardiovascular diseases.
Warning! If you are going to substantial increase your niacin intake above RDA levels then you should always discuss it first with your doctor. The reason why is that niacin can cause side effects when taken in high doses. This brings us to the reason why niacin has fallen out of favor in the treatment of cholesterol?
Flushing and Other Niacin Side Effects!
From over-the-counter supplements to prescription formulations, niacin comes in a variety of forms. Some are fast-acting and others are designed to act over a long period thru time-released encapsulation.
For therapeutic use to positively affecting your cholesterol levels, usually high doses of niacin (1000 milligrams or more) are administered. At this level most people will experience a “niacin flush” which is a temporary shunting (or vasodilation) of blood to the skin surface. The flush usually lasts for 15 to 30 minutes and will cause the skin to redden, feel warm to the touch, and may cause you to perspire. Although annoying, the “niacin flush” isn’t harmful. Some have found that taking an aspirin shortly before you take your niacin can help to alleviate this flushing effect. Hot drinks and alcohol can increase this flushing so it’s recommended that you avoid them when taking niacin.
To reduce the potential for flushing, some people will take a time-released niacin formulation. While this may help reduce the non-threatening, but inconvenient flushing, it increases the risk of harmful liver enzyme elevation. The continuous release of niacin into the liver can disrupt healthy methylation reactions that are essential to liver health. Fast acting niacin supplements do not usually present this problem.
It’s also important to note that therapeutic use of niacin does not mean taking 1000 milligrams at one time. Usually the total intake recommended by a qualified health practitioner is divided throughout the day in levels of 300 to 600 mg of niacin taken twice per day, and with a meal to help offset potential side effects.
Other potential side effects from therapeutic levels of niacin can include upset stomach, headache, dizziness from a drop in blood pressure, itching, increased blood sugar levels, and elevated liver enzymes. Thus, people with liver or kidney problems and diabetics need to take extra precaution. Working with a qualified health professional can help you find the right dose and form of niacin to help minimize these side effects.
Niacin, Statin Drugs and Current Research!
Niacin, like nitric oxide, seems to help statin drugs work more effectively. Research has shown that niacin, when used with some statins, can increase HDL “Good” cholesterol by 50 percent or more. Additionally, this combination also reduces LDL “Bad” cholesterol levels more than when statins are used by themselves.
Statin drugs have some very specific and dangerous side effects so utilizing other natural methods to help lower, and potentially eliminate statin usage can be beneficial for long term heart health. However, it is always best to check with your doctor and pharmacist before taking niacin with another medication to avoid any potential and dangerous drug interactions.
It’s also important to note that researchers are coming close to finding a niacin formulation that helps to prevent the dreaded niacin flush. Much of this research is at Duke University Medical Center and concentrates on G proteins. According to Robert Walters, M.D.,
“Niacin stimulates production of a vasodilator that dramatically increases blood flow to the face, causing the flush and the hot, prickly sensation – and beta-arrestin 1 is the culprit that enables that to happen. Interestingly, however, beta-arrestin 1 plays no role whatsoever in niacin’s ability to lower cholesterol and fatty acids. The G proteins do that.”
There is also a growing body of work looking at how flavonols – a class of plant-derived polyphenols – could inhibit this niacin flush. The two flavonoids that have shown the greatest potential are quercetin and luteolin. Quercetin is a compound that has been shown to promote endothelial function while supporting healthy blood glucose levels. Luteolin seems to suppress dangerous cytokines that are associated with flushing and other inflammatory reactions. A small human clinical trial used a combination of niacin, quercetin and luteolin to reduce the unpleasant side effects of niacin supplementation by an estimated 70 percent. This trial needs to be tested on a larger population base to confirm these findings.
Because over-the-counter niacin supplements can be just as good as prescription niacin in helping to increase your HDL cholesterol and lower your LDL cholesterol many people are opting for this method in their cholesterol reduction battle. Just make sure that it’s a reputable company that standardizes its ingredients and formulations. And, it’s important to note that if you choose to use dosages of niacin higher than the standard RDA, please consult with a qualified medical practitioner so that a proper program can be developed to your specific health goals.
Together we can work to save a million lives!
Dan Hammer
The information contained in this blog is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contain in this blogging website has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.
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