The Need for L-Citrulline!

L-CitrullineWhat’s a picture of a watermelon have to do with L-citrulline? I’ll answer that in a little bit. Let’s first start with nitric oxide and L-arginine.

So much of the buzz about improved nitric oxide production centers on L-arginine. Unfortunately, many forget about L-citrulline. While L-arginine is the main amino acid used by the endothelial cells to create nitric oxide, some feel that L-citrulline is actually more important for long term nitric oxide production and improved cardiovascular health.

I bring this to your attention because I’m in the process of developing an educational module designed to help those with sickle cell anemia. One complication for those who have sickle cell anemia is the negative effects of the enzyme arginase.

Arginase is an enzyme located primarily in the liver. It is used to help complete the fifth and final step in the urea cycle. This urea cycle helps your body dispose of harmful ammonia. It is also found in the kidneys and prostate. Some research indicates that arginase is located in the mitochondria of most cells. The mitochondria are the portions of your cells that produce the bulk of your energy.

Arginase and Circulation!

While arginase has a useful role in the body it can also play a negative role in circulation. Why? Because arginase destroys L-arginine. Your endothelial cells convert the amino acid L-arginine to nitric oxide. Nitric oxide is the master signaling molecule of your cardiovascular system. It regulates blood pressure, helps to improve blood flow, keeps blood platelet cells from sticking together, prevents LDL cholesterol from adhering to the vascular walls and is a factor in a host of other very important health issues.

Everyone carries arginase in their bloodstream which can have some affect on lowering nitric oxide production. This is a bigger problem in the African American community especially for those with sickle cell disease. Thankfully, your body has an alternative pathway that enables the endothelial cells to create nitric oxide. It’s through the amino acid L-citrulline.

How Important is L-citrulline?

Well, let me introduce you to Dr. Louis J. Ignarro to answer that question. Dr. Ignarro is the 1998 Nobel Laureate in Medicine. He, and two other American researchers, were awarded the Nobel Prize for their discovery of how the endothelial cells create nitric oxide (NO) from the essential amino acid L-arginine. In Dr. Ignarro’s book, NO More Heart Disease, he makes the following statement:

My research shows that if you take only L-arginine, which is the dominant producer of NO, you will not receive the maximum benefit. I have found that by including the synergistic partner L-citrulline, your ability to boost NO production is greatly enhanced over the effects of L-arginine alone.”

Your endothelial cells use an alternative pathway to convert L-citrulline to nitric oxide. This helps bypass the arginase enzyme so that good nitric oxide production can be restored. Plus, L-citrulline provides a 24 to 36 hour window for enhanced nitric oxide production whereas L-arginine by itself usually only has a 30 minute to 2 hour window of enhanced nitric oxide production.

This means that L-arginine can help start the process of nitric oxide production to improve circulation. Then the L-citrulline can take over to continue the improved nitric oxide production helping to maintain improved circulation.

Dr. Ignarro goes on to say, “Any supplement program that does not contain L-citrulline and antioxidants to augment the L-arginine – and most on the market do not – is missing out on a major piece of the potential of NO to improve your cardiovascular health.” This statement and the information I shared so far leads to two important questions:

What foods contain L-arginine and L-citrulline?

Is it better to get these critical amino acids through food or supplementation?

I’m preparing two new videos to help answers these questions and to visibly show you the best and most effective method for enhanced nitric oxide production. But the first question brings me back to the picture of the watermelon.

The Watermelon!

In March of 2007 there was a study published in the Journal of Nutrition. The article was entitled “Watermelon consumption increases plasma arginine concentrations in adults.” This article created a significant buzz on the internet because L-arginine is needed to produce nitric oxide which is needed for a male erection. In the media, watermelon became the new and natural Viagra. While this study didn’t examine the effects on male anatomy it did provide some very important information confirming the body’s ability to convert L-citrulline to L-arginine to improve nitric oxide production.

The study subjects were given either 780 grams (equivalent of 1 g of citrulline) of watermelon or 1560 grams (equivalent of 2 g of citrulline) of watermelon. The study lasted three weeks. At the end of the study the 780 grams of watermelon group saw a 12% increase in fasting plasma arginine concentrations. The 1560 grams of watermelon group saw a 22% increase when compared to a control group that received no watermelon.

This clearly shows that your body has an alternative pathway for creating the necessary L-arginine from the amino acid L-citrulline.

So, is eating watermelon an effective way to improve nitric oxide production?

Well, the 780 grams of watermelon is equal to 1.72 pounds. The 1560 grams of watermelon is equal to 3.43 pounds. That’s a lot of watermelon to eat even if you like it. Plus, it includes the rind, that thick green outer covering of the watermelon. I believe there’s an easier way to achieve an even better result. I’ll show you in one of my upcoming videos.

Together we can work to save a million lives!

Dan Hammer

Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contained in this article about L-Citrulline has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.

Quick Order Page for ProArgi-9 Plus!

I’d like you to know about the new Quick Order Page for ProArgi-9 Plus. This page provides one central location to order this “remarkable” and unique product. It’s available to my existing customers and to those considering ProArgi-9 Plus. This short video tutorial will show you how to quickly and effectively use this page.

ProArgi-9 Plus is the nutritional supplement at the heart of the High Desert Heart Institute study. This study has had a profound impact on the method of treatment for the patients at the High Desert Heart Institute.

ProArgi-9 Plus is the product created by Dr. J. Joseph Prendergast. Dr. Joe (as he prefers to call himself) has used this L-arginine / L-citrulline supplement with other heart healthy ingredients to benefit over 7,000 patients of which 80% are diabetics. For those who have followed his advice on how to use this supplement, Dr. Joe made the following recent statement:

. . . 80% of the people have diabetes and in 17 years we have had no problems with strokes, no problems with heart attacks, I’ve not even had any admissions in 17 years. So this is a striking example in how we can use this product for real power for health. . . “

If you’re interested in ordering ProArgi-9 Plus then please click on Quick Order Page for ProArgi-9 Plus.” Once on the page I would ask you to Bookmark it so that you can conveniently return to it whenever you need to.

Additionally, if you watched the video you know that we are close to releasing our first information module “Help with Pain from Sickle Cell Anemia!” Our goal is to have this information platform up on the internet sometime between March 31st and April 15th. When it becomes live we will announce it here and provide you with a link to this platform.

Our next information module will be “Help with Complications from Diabetes!” We hope to have this one completed by the end of May. Please feel free to share the information with family and friends.

Together we can work to save a million lives!

Dan Hammer

Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contained in this article about ProArgi-9 Plus has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.

African Americans and Cardiovascular Disease!

African American DoctorCardiovascular disease is the number one killer of people worldwide.  Unfortunately, it’s even worse for the African American community.  There are several reasons for this and hopefully this article will help begin the process of changing this sad reality.   To address these reasons I’ve broken this article into three parts:  The Bad News, Several Underlining Causes, and Steps to Decrease Your Risk! 

The Bad News! 

It’s important for you to understand the depth of cardiovascular disease confronting the African American community.  Below is a brief summary of the ailments that directly affect African Americans:  

  • Diabetes.  Type 2 diabetes has grown to epidemic proportions in the United States.  People with diabetes have a greater risk for stroke, heart disease and circulatory issues.  Most diabetes-related deaths are due to cardiovascular disease.  Twice as many African Americans will develop diabetes when compared to the Caucasian community. 
  • Erectile Dysfunction.  Erectile dysfunction affects 50% of the male population over the age 40 and is even greater in the African American community. 
  • Heart Disease.  African American women in the age range of 25-44 have a 2.5 times greater risk of coronary heart disease and African American men have a 1.5 times greater risk than the Caucasian community. 
  • High Blood Pressure.  The number one risk factor for stroke is high blood pressure, and 1 out of every 3 African Americans suffers from this ailment.  The American Heart Association estimates that 28% of African American adults and more than 66% of African Americans over the age of 60 have high blood pressure.  
  • High Cholesterol Levels.  High blood cholesterol is a significant risk factor for heart disease.  Unfortunately 50% of African American men and 54% of women have too much cholesterol circulating in their blood stream. 
  • Sickle Cell Anemia.  It’s estimated that one in 12 African Americans has sickle cell trait and one out of every 400 births have sickle cell anemia. 
  • Stroke.  African Americans are twice as likely to die from a stroke as Caucasians.  The rate of having their first stroke is almost doubled that of Caucasians.  One half of all African American women will die from either a stroke or heart disease.  For those with sickle cell anemia, 11% will have experienced a stroke by the age of 20.  

That’s quite a list of ailments affecting African Americans.  If you look closely at all seven health issues you will see that the common denominator is your cardiovascular system.     

The key for reducing your health risk for these cardiovascular diseases is to make sure your cardiovascular system is as healthy as possible.  This article will provide several steps to address this but before we do you need to understand some of the underlining causes of why cardiovascular disease is so prevalent in the African American community. 

Several Underlining Causes! 

Within your cardiovascular system there is one particular essential amino acid, one critical signaling molecule, one critical cellular structure and one detrimental enzyme that directly impact its overall health.  They are: 

  • L-arginine – Key Essential Amino Acid
  • Nitric Oxide – Key Signaling Molecule
  • Endothelial Cells – Key Cellular Structure
  • Arginase – Key Detrimental Enzyme 

The first three keys of L-arginine, nitric oxide and endothelial cells are interrelated so we will examine them as a whole.  The endothelial cells form the interior lining of all your blood vessels.  These cells ultimately determine your cardiovascular health.  One function of these endothelial cells is to take the essential amino acid L-arginine and convert it into the signaling molecule nitric oxide.  Very simply, you couldn’t live without nitric oxide! 

Nitric oxide is the master signaling molecule of the cardiovascular system.  It regulates blood vessel tone and flexibility.  Its production is completely dependent upon the health of your endothelial cells and an adequate supply of the essential amino acid L-arginine.  Here are some of the benefits of nitric oxide: 

  • Nitric oxide regulates the muscle tone of blood vessels to have a major impact on controlling blood pressure.  This directly relates to high blood pressure.
  • Nitric oxide causes penile erections by dilating blood vessels.  This directly relates to erectile dysfunction.
  • Nitric oxide prevents blood platelet cells from grouping together in a clot.  This minimizes blockages in the blood vessels to reduce the risk for heart attacks, strokes and complications from sickle cell anemia.
  • Nitric oxide promotes vascular reparative mechanisms and is one of the keys to reversing atherosclerosis.  This helps to reduce the damage caused by high cholesterol levels and assists in preventing the vascular complications of diabetes. 

Nitric oxide is literally involved in all cells to help keep you fit and healthy.  It’s important to understand that this interrelationship between the endothelial cells, L-arginine and nitric oxide production is common for all races.  

What is not common is a genetic polymorphism inherent to the African American population.  This genetic polymorphism causes African Americans to have higher levels of an enzyme called arginase in their blood stream.  Arginase destroys L-arginine which is the main ingredient for creating nitric oxide in the body. 

For the African American community, nitric oxide production is compromised on both sides of the equation!

On the front end, the enzyme arginase destroys L-arginine which interferes with the production of nitric oxide.  On the back end, the health of your endothelial cells determines how much of the remaining L-arginine can be converted to nitric oxide.  Unfortunately, your endothelial cells are damaged by high blood pressure, high sugar levels, high cholesterol, smoking, and oxidative stress.  This damage reduces the production of nitric oxide which compounds the problem and increases the risk for cardiovascular disease. 

Steps to Decrease Your Risk! 

Given the above information there are several important steps to decreasing your risk for cardiovascular disease.      

Step 1 – Monitor your blood pressure.  High blood pressure damages your endothelial cells.  If you do not know what your blood pressure is then you need to go to your doctor’s office, local pharmacy or health clinic and get your blood pressure taken.  If you have high blood pressure, then you need to take steps to bring it back into a normal range.  This is your first and most important step.  It’s so important that the Black Barbershop Health Outreach Program was established to exclusively address the issue of high blood pressure on a national level.  For more information on participating barbershops, go to http://www.blackbarbershop.org/ .

Step 2 – Monitor your blood sugar and cholesterol levels.  High sugar and cholesterol levels damage your endothelial cells.  Diet is extremely important for both of these areas.  One simple but highly effective step to stabilize your blood sugar levels and help your body naturally reduce its cholesterol levels is to increase your fiber intake.  Including dry beans or legumes into your diet is a quick and delicious way to increase your fiber intake. In fact studies have shown that consuming dry beans four times or more per week, compared with less than once a week, lowered the risk of cardiovascular disease by 22 percent. 

Step 3 – Stop smoking!  Smoking damages your endothelial cells.  This is a nasty habit that is extremely hard to break.  Part of the process is having a motivation greater than the habit.  

If your very life isn’t motivation enough, then maybe for the men your sex life is! 

Your endothelial cells control your nitric oxide production.  Your nitric oxide levels control an erection.  No nitric oxide no sex!  Every puff on your cigarette is destroying your endothelial cells which lowers your nitric oxide level and reduces your chances of having good sex.  

Step 4 – Increase L-arginine intake!  In addition to protecting your endothelial cells, you need to get an adequate intake of the essential amino acid L-arginine which is found in foods like milk, cheese, yogurt, meat, and other protein sources.  Most people take in enough L-arginine to meet basic bodily needs.  However, when your diet is poor and/or your stress level is high, then this essential amino acid will be lacking.  Couple this with the enzyme arginase that destroys L-arginine and the potential risk for cardiovascular disease is increased. 

Step 5 – Use L-citrulline to bypass Arginase!  Your body will convert the amino acid L-citrulline into L-arginine to help maintain its production of nitric oxide.  This process also helps to bypass the arginase enzyme since it has no effect on L-citrulline.  Having a good supply of L-citrulline provides the body with a 24 to 36 hour window in the production of nitric oxide.  This is important for all population groups but it’s critically important for African Americans especially those with sickle cell anemia.  Unfortunately, L-citrulline is not prevalent in most foods we eat.  Thus, supplementation is usually required. 

Step 6 – Consider ProArgi-9 Plus!  There is a clinically proven nutritional supplement called ProArgi-9 Plus which has the ability to bring in the proper balance of L-arginine and L-citrulline.  This product also combines other heart healthy ingredients to significantly improve the health of the endothelial cells and their ability to properly produce nitric oxide.  The most recent validation for this product is the remarkable results obtain for 33 congestive heart failure patients in the High Desert Heart Institute study.  

Conclusion

You have the power to directly improve the health of your endothelial cells to significantly reduce your risk for cardiovascular disease.  And, for those with sickle cell anemia, you can help to reduce your symptoms.  It all centers on helping your endothelial cells function optimally, with an above average supply of L-arginine, and a way to bypass the arginase enzyme so that nitric oxide is properly produced.  Improved production of nitric oxide is critical to helping African Americans decrease their risk for cardiovascular disease!

Together we can work to save a million lives! 

Dan Hammer 

Dan Hammer has a background in biology, chemistry and exercise physiology.  He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.   
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam.  The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.