Food versus Supplementation for L-Arginine and L-Citrulline!

In my last post I showed you the amount of food you would need to consume to take in 5 grams of L-arginine, 1 gram of L-citrulline, and 400 micrograms of folic acid. Three key nutrients for cardiovascular health.

I’m using these quantities because most research shows that to receive a therapeutic benefit you would need to consume these amounts. L-arginine and L-citrulline are necessary for improved nitric oxide production. Folic acid is needed for proper red blood cell production and heart health. When people realize all the food they need to eat, and the limited menu they have to choose from, they begin to ask the question:

Is it better to get L-Arginine and

L-Citrulline through food or supplementation?

This video answers that question. Enjoy it and I’ll have some observations to make after you watch it:

Observation 1 – As you saw from the video there is a strong case for proper supplementation especially when you factor in calories, cost, and convenience. The cheapest meal you could consume was 12 ounces of black beans, 2.7 pounds of watermelon and 1 cup of Total cereal at a cost of $4.45. This meal would also bring 813 calories into your body.

Observation 2 – Instead of conventional food you had two other choices. Your first choice would be to go to your local health food store and purchase three supplements: L-Arginine, L-Citrulline and Folic Acid. While this is the least expensive way at $1.86 it also means taking 13 capsules per day. You would need to take 1 Folic Acid tablet, 2 L-Citrulline capsules, and 10 L-Arginine capsules.

Just remember, if you choose supplementation then make sure that you only use the natural “L” form of the amino acid and never the “D” or synthetic form. Additionally, make sure that the product uses “pharmaceutical grade” ingredients. This ensures that the ingredients meet exacting standards so that product quality and consistency is maintained from batch to batch. This is especially important for L-arginine products.

There are a lot of “nitric oxide” products in the marketplace. They are widely used by weight lifters to help them experience improved workouts and increased muscle mass. But, “nitric oxide” products are not to be played around with. It’s extremely important to know who the product formulator is and what experience they have in properly isolating L-arginine so that it can be effectively brought into your system.

It’s also important to know if the product you’re considering has any clinical studies associated with it. Clinical studies that can support its effectiveness in truly improving the health of your endothelial cells so that they can properly produce higher levels of nitric oxide.

Observation 3 – As you know I’m a firm believer in ProArgi-9 Plus. It’s your other choice. While it’s slightly more than the supplements, it does provide you with 9 additional ingredients all designed to help improve cardiovascular health. When compared to the food choices, it is $2.00 cheaper and significantly lower in calories. This allows me to properly support my cardiovascular system, especially my endothelial cells. It also allows me more flexibility in my diet for other healthy organic foods. While there are a handful of other good products in the marketplace, none have the clinical studies to support their effectiveness like ProArgi-9 Plus.

Observation 4 – I made a pitch for eating organic foods at the end of the video. While organic foods are certainly higher in cost than the store bought brands it’s worth the extra expense in helping improve liver function. As I shared in the video, every added chemical ingredient has to be processed by your liver, which takes away its ability to help your body in other needed areas. If you want to have your eyes opened to the food industry and how they manufacturer our food sources, then rent the DVD Food Inc. from your favorite rental source.

Well, I hope this video and post has been educational and beneficial in helping you see proper supplementation as a complement to making good food choices.

Together we can work to save a million lives!

Dan Hammer

Dan Hammer has a background in biology, chemistry and exercise physiology. He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years.
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam. The information contained in this article about L-Arginine and L-Citrulline has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.

Sickle Cell Disease – 14 Helpful Steps!

African American Doctor 2Sickle cell disease primarily affects people of African, African American, Mediterranean, Middle Eastern, and Asian Indian ancestry. There is also a growing segment in the Latino-American population particularly those of Caribbean, Central American, and South American ancestry that are affect by this disease.  In the United States one out of every 400 births has this disease.  The most common type of sickle cell disease is sickle cell anemia.  In my companion article “African Americans and Sickle Cell Anemia” I covered a lot of material about the cause and symptoms of this disease.  

This article will provide you with 14 helpful steps in managing this disease.  Plus, new research confirms the importance of proper nitric oxide production in helping to reduce the painful symptoms of sickle cell anemia. 

Brief Overview of Sickle Cell Disease! 

Sickle cell disease is caused by a genetic change in the hemoglobin portion of the red blood cell.  Hemoglobin is the oxygen-carrying protein inside the red blood cell.  Normal red blood cells are oval and flexible.  Red blood cells in sickle cell disease have a tendency to reshape themselves into rod-like structures that resemble the curved blade of a sickle; thus, the term sickle cell.  

Sickle cells have a much shorter life span than normal red blood cells.  This results in chronic anemia and reduced oxygen to the tissues of the body.  In addition, sickle cells are less flexible than normal red blood cells.  This presents a problem.  They become trapped in the small blood vessels preventing blood flow to the body’s tissues and organs.  This compromises the delivery of oxygen and usually results in pain and potential damage to the associated tissues and organs. 

Recent Research – The Importance of Nitric Oxide! 

Researchers at Duke University and Howard Hughes Medical Institute recently discovered one of the keys to the cause of pain in sickle cell disease.  Their findings were reported in the January 31, 2005 Proceedings of the National Academy of Sciences.  Their research showed that when normal red blood cells move through the arteries they release a signaling molecule that tells the arterial walls to expand.  The signaling molecule is nitric oxide.  Nitric oxide causes the smooth muscle in the wall of the blood vessel to relax.  This helps to open up the blood vessel allowing the red blood cells to pass through it.  

The researchers at Duke University discovered that when red blood cells distort to their sickle shape, the walls of the arteries don’t expand.  This distorted shape of the sickle cells, combined with the fact that they tend to clump together, ends up blocking blood flow through these small arteries and capillaries.  The Duke researchers also noted that as the blood pulses, the walls of the arteries didn’t expand like they do when normal red blood cells are present. 

Their research also noted that the degree of nitric oxide deficiency directly correlated with symptom severity for those with sickle cell disease.  This means that the less nitric oxide produced the greater the pain.  The Duke/HHMI study found that when nitric oxide was administered to people with sickle cell anemia their symptoms were relieved.  One of the conclusions from this study was that abnormal nitric oxide processing may be the real cause of sickle cell circulatory restrictions.  In addition to the Duke/HHMI study, several other studies have demonstrated that when nitric oxide is administrated to people with sickle cell anemia their symptoms are greatly reduced.         

1998 Nobel Prize in Medicine! 

In 1998 the Nobel Prize in Medicine was award to three American researchers.  Part of what came out of their research was that the primary pathway for creating nitric oxide in the body came from an essential amino acid called L-arginine.  L-arginine is called an essential amino acid because your body cannot produce it.  It must be brought into your body through your diet.  L-arginine is found in foods like milk, cheese, yogurt, meat, and other proteins.  In fact, L-arginine is considered one of the most important molecules ever discovered.  Columbia University refers to L-arginine as the “MAGIC BULLET” for the cardiovascular system.  

Genetic Polymorphism and the Importance of L-citrulline! 

Unfortunately, there is a genetic polymorphism common to the African-American community.  Many African-Americans produce too much of an enzyme called arginase.  In the bloodstream, arginase destroys L-arginine so that it is no longer available for the production of nitric oxide.  This compounds the problem of not have a sufficient supply of nitric oxide available to help relax the small arterial walls.  This is especially important when the red blood cells change into their sickle form. 

Fortunately, there is an amino acid that your body can convert to L-arginine to help bypass the arginase enzyme.  It is L-citrulline.  A recent paper (January 18, 2010) entitled Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease by MF McCarty discussed this very issue.  Here is a brief but important quote from this paper: 

“Suboptimal endothelial arginine levels, reflecting increased plasma arginase activity and elevated ADMA, contribute to the loss of NO bioactivity in sickle cell disease; supplementation with the arginine precursor citrulline may ameliorate this defect.” 

This means that proper dietary supplementation using the amino acid L-citrulline can help the body bypass the destructive effects of the enzyme arginase so that proper nitric oxide production can be restored.  Since nitric oxide regulates the muscle tone of blood vessels this becomes extremely important in preventing blockages.  Additionally, nitric oxide prevents blood platelet cells from grouping together in a clot which also helps to prevent blockages in the blood vessels. 

14 Steps to Help Those with Sickle Cell Disease!

Understanding the past and most current research will help to chart a plan of action to help those who suffer from sickle cell disease.  The following 14 steps will help in this process.  However, please remember that these steps are for informational purposes only and is not a substitute for professional medical advice, examination, diagnosis, or treatment.  Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding this or any medical condition.  Never disregard professional medical advice or delay in seeking it because of something you have read in this article.  If you think you may have a medical emergency, always call your doctor or 911 immediately. 

Step 1 – Proper hydration.  It’s estimated that 75% of Americans have mild, chronic dehydration.  This will affect blood flow so getting the proper amount of water on a daily basis is critically important.  And, it must be pure water!  Pop, coffee, diet soda, alcohol, or other doctored beverages do not count.  Your body must replace 2-3 quarts of water everyday.  As a rule of thumb, for every 15 lbs of weight, you need 8 ounces (1 cup) of water.   

Step 2 – Stay warm.  Cold reduces blood flow because capillaries constrict.  If you live in a cold environment, then take extra precaution to keep your extremities, especially fingers and toes, properly protected.  

Step 3 – Avoid high altitudes.  Geographic locations with high elevations should be avoided due to the reduce level of oxygen in the atmosphere.

Step 4 – Exercise.  Intense exercise should be avoided but mild to moderate aerobic exercise can be a benefit.  Exercise improves blood flow.  Research has shown that blood flow across the endothelial cells will stimulate nitric oxide production.  Additionally, exercise will produce collateral capillary beds that can aid in providing alternative pathways for blood flow when an arterial pathway becomes blocked.  Collateral capillary beds are extremely important for those with sickle cell disease.  However, before starting an exercise program, you should always consult your physician.  

Step 5 – L-arginine supplementation.  The body utilizes L-arginine to create nitric oxide.  Nitric oxide is necessary for the proper function of the cardiovascular system especially in the control of the elasticity of the arterial walls.  

Now, before you go out and start buying L-arginine supplements you need to be aware of the dark side of this amino acid.  L-arginine ingested in its pure form tastes terrible.  By itself, L-arginine can have some serious side effects.  Because L-arginine can have negative side effects it must be properly formulated if it is to have a positive impact on helping the body create nitric oxide.  It is critical that the company and the person who formulates an L-arginine product have both experience and clinical documentation to its effectiveness.

From my experience, the best L-arginine supplement comes from Synergy WorldWide.  Their product, ProArgi-9 Plus, was developed by Dr. Joe Prendergast who is Board Certified in Internal Medicine as well as Endocrinology and Metabolism.  Dr. Prendergast is an expert in integrative L-arginine therapy and has been using it in his practice since 1991.  As a precaution, you should discuss this with both your physician and pharmacist especially if you are on any type of medication. 

Step 6 – L-citrulline supplementation.  This step is as important as step number 5 and maybe even more important.  Usually L-arginine provides a 30 minute to 2 hour window of improved nitric oxide production.  By supplementing with L-citrulline that window of improved nitric oxide production increases to 24 to 36 hours.  When properly combined with L-arginine and other important heart healthy ingredients, this dramatically improves the endothelial cells ability to properly produce nitric oxide, the master signaling molecule for the cardiovascular system.  This is an important component in ProArgi-9 Plus

Step 7 – Rest.  It’s important to get adequate rest since stress can have a negative effect on your overall health and wellness as well as lowering your immune system. 

Step 8 – Support your immune system.  There is so much that could be said in this area.  Increasing your consumption of antioxidant rich fruits and vegetables would be an important first step.  Daily consumption of at least 500 mg of vitamin C would help both the immune system and liver function.  

Step 9 – Support your liver.  Again, there is so much that could be said in this area.  Adequate amounts of green leafy vegetables with proper water intake are two good first steps to help the liver.  Taking 500 mg of vitamin C will help increase the rate of synthesis of glutathione which is a major component in liver detoxification. 

Step 10 – Avoid people with colds and flu.  Try not to place yourself in situations that allow for infections to occur.  This may require you to use a mask if your work or school environment is compromised with illness issues. 

Step 11 – Immunizations.  Stay up-to-date with the proper immunizations.  Work with your health care provider to set up a schedule so that all the proper steps are taken to stay on top of this area. 

Step 12 – Folic acid supplementation.  Folic acid is a necessary component for the production of red blood cells.  The recommended daily amount for adults is 400 micrograms and 600 micrograms in pregnancy.  If you are thinking about taking a larger amount, then you should discuss this with both your physician and pharmacist.  This is an important component in ProArgi-9 Plus.

Step 13 – Support groups.  Because of the emotional challenges that come with sickle cell disease it always helps to find a support group to share frustrations, challenges, hopes, and successes. 

Step 14 – Family planning.  Due to the genetic nature of sickle cell disease, it’s always helpful to discuss options with a family practitioner who has experience in genetic counseling.  

Because of the genetic nature of sickle cell disease there is no pill to cure it.  This can leave individuals and family members feeling helpless in their battle against the symptoms of this disease.  That’s why it’s important to discuss these 14 steps with a qualified physician.  Together you can develop a plan of action; one that will empower you to have better control over the symptoms of sickle cell disease. 

Together we can work to save a million lives! 

Dan Hammer 

Dan Hammer has a background in biology, chemistry and exercise physiology.  He used to run one of the largest health club operations in the Chicagoland area and has been helping people with their wellness issues for more than 25 years. 
The information contained in this article is for general information purposes only and never as a substitute for professional medical advice or medical exam.  The information contain in this article has not been evaluated by the Food and Drug Administration and should not be used to diagnose, treat, cure or prevent any disease without the supervision of a qualified medical doctor.